The project aims to determine the control mechanism of adipose tissue plasticity and function, to ensure the implementation of prevention strategies for obesity associated metabolic complications, and to study the influence of obesity on the liver lipid network that causes fatty liver. The project will explore the molecular mechanisms that control energy consumption and fat deposition, as well as the mechanism that controls the division of energy to oxidation or storage. The research focuses on obesity and diabetes, and tries to understand why obesity can lead to cardiometabolic complications. The scope of the research includes how to prevent lipid accumulation in these organs by activating brown fat, understand why obesity causes metabolic and cardiovascular problems, and provide reasonable treatments for mechanically driven treatments to prevent complications.

The research results of this project will help to identify molecular targets required for therapeutic intervention and provide a new theoretical basis for identifying treatment strategies for obesity-related metabolic diseases, such as diabetes, fatty liver, and cardiometabolic complications based on the concept of lipotoxicity and adipose tissue dysfunction.