DropBioApp Engineering Droplet-based Microfluidic Platform

Tuomas Knowles

Principal Investigator

Tuomas Knowles is Professor of Physical Chemistry and Biophysics at the Department of Chemistry and at the Cavendish Laboratory at the University of Cambridge. He is the co-director of the Cambridge Centre for Misfolding Diseases and a Fellow of St John’s College, Cambridge.
Professor Knowles is the co-founder of four biotechnology companies: Fluidic Analytics, Wren Therapeutics, Xampla and Transition Bio. He was also the Cambridge Enterprise Academic Entrepreneur of the year in 2019.

Yu Ziyi

Co- PI

The project relies on the Centre, and will build up a set of microfluidic facilities for the Centre including a microfluidic device fabrication workstation, a fluorescence detection rig, and microdroplet sorting capability. This can be used for microdroplets generation, materials synthesis, cell encapsulation, fluorescence sorting, etc.

 

The project will form a unique single-cell sequencing method based on microfluidic technology, the preparation technology of functional medical microspheres, and a prototype that realizes the integration of high-throughput microfluidic screening, etc., transiting from a research-scale microfluidic technology to industrial-scale manufacturing and production, and will cooperate with local companies in the fields of biomaterials, single-cell analysis, drug discovery and tissue engineering to establish a formal biotechnology business entity with an aim to use the research results for commercial purposes.